ABSTRACT
Objective To discuss the clinical effect of Xipayinguyinye on oral bacteria in vitro and gingivitis in vivo.Methods Took the method of agar dilution to measure the minimum inhibitory concentration (MIC) of Xipayinguyinye on Porphyromonas gingivalis ( P.gingivalis),Prevotella intermedia ( P.intermedia ) and Fusobacterium nucleatum( F.nucleatum)in vitro;choose 112 patients with simple gingivitis and they were randomly divided into the research group and control group.The research group(56 cases)received the treatment of Xipayiguyinye,while the control group(56 cases)received the treatment without effect components.Both groups received 7 days of treatment and then observed the changes of sulcus bleeding index ( SBI ) and plaque index ( PLI ) before and after the treatment.Results MICof Xipayiguyinye in vitro was 1.0g/L for P.gingivalis and F.nucleatum and 0.5g/L for P.intermedia.There was no statistifically significant difference in SBI and PLI between two groups before the treatment(P ＞0.05) ;there was significant difference in SBI and PLI of research group before and after the treatment ( P ＜ 0.05 ) ; there was no significant difference in SBI and PLI of control group before and after the treatment( P ＞ 0.05 ) ;there was significant difference in SBI and PLI in SBI and PLI between two groups after the treatment ( P ＜ 0.05 ).Conclusion Xipayiguyinye could prevent bacteriostasis well and decrease the accumulation of dental plaque,reduce SBI and improve the health of the gingiva in vivo.
ABSTRACT
ObjectiveTo explore salivary concentration of carcinoembryonic antigen (CEA),interleukin (IL)-6,IL-8 in oral squamous cell carcinoma and its' clinical significance.MethodsForty-two cases with oral squamous cell carcinoma were selected as experience group and 50 healthy persons as control group.ELISA method was performed to detect CEA,IL-6,IL-8 level of salivary and serum in two groups.ResultsThe salivary concentration of CEA,IL-6 and IL-8 was (62.37 ± 20.80)μ g/L,(79.12 ± 30.26)ng/L,( 834.61 ± 231.85 ) ng/L respectively in experience group,(25.72 ± 12.65 ) μ g/L,(0.58 ± 0.25 ) ng/L,(209.71 ± 67.92) ng/L in control group.There was significant difference between two groups(P＜ 0.01 ).The serum concentration of CEA,IL-6 and IL-8 was(61.15 ± 23.69)μ g/L,(58.17 ± 12.83) ng/L,(852.31 ±172.97) ng/L respectively in experience group,and IL-6 level of serum were much lower than that of salivary (P ＜ 0.05).ConclusionsCEA,IL-6 and IL-8 can be biomarkers of oral squamous cell carcinoma.Salivary detection is an ideal auxiliary diagnosis method for its simplicity and sensitivity.